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1. Medicines which increase the production of metabolising enzymes are called enzyme inducers?
2. Medicines which decrease the production of metabolising enzymes are called enzyme inhibitors?
3. Medicines that are enzyme inducers can cause lower plasma levels of other medicines?
4. Medicines that are enzyme inhibitors can cause higher plasma levels of other medicines?
5. The kidney can easily excrete lipophilic medicines?
6. The three basic processes that effect excretion via the kidney are glomerular filtration, tubular secretion and diffusion across tubular epithelium?
7. Some medicines are excreted into the bile and eventually into the faeces?
8. All medicines need to have their doses adjusted in patients with renal impairment?
9. Elderly people and neonates have decreased renal function and therefore dose adjustment is often required?
10. The half-life is the time taken for half the dose of a medicine to be absorbed?
Question 1: The correct answer is True Enzyme inducers increase metabolising enzymes which reduces the amount of drug available at the site of action.
Question 2: The correct answer is True Enzyme inhibitors reduce metabolising enzymes which increases the amount of drug available.
Question 3: The correct answer is True Enhanced production of liver enzymes increase drug breakdown resulting in lower plasma levels.
Question 4: The correct answer is True Reduced production of liver enzymes decrease drug breakdown resulting in higher plasma levels.
Question 5: The correct answer is True Drugs must be in a hydrosoluble form to be excreted in the urine.
Question 6: The correct answer is True The three basic processes that effect excretion via the kidney are glomerular filtration, tubular secretion and diffusion across tubular epithelium.
Question 7: The correct answer is True Some drugs are transferred from the plasma into bile and enter the gastrointestinal tract from the gallbladder to eventually be excreted in faeces.
Question 8: The correct answer is False Not all drugs are predominantly renally excreted and therefore do not always need a dose adjustment.
Question 9: The correct answer is True Renal function declines with age and neonatal renal function is not fully developed which may require a dose adjustment - adult renal function is not reached until approximately18 months of age.
Question 10: The correct answer is False The half life of a drugs is the time it takes for the plasma concentration to fall by half its original value.
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